Superiority and non-inferiority: two sides of the same coin? Full Text

Harmony serves users and participating nodes, with a decentralized, yet efficiently scalable solution so users pay minimal fees to easily migrate Ethereum, Binance, and other decentralized blockchain tokens. The fully diluted market value is referring to a cryptocurrency’s market cap when/if its total supply is issued. Available supply or circulating supply fundamental review of two ftse listed sto .. is the best approximation of coins or tokens in circulation and publicly available. The SECOND-LINE and EARNEST trials both found no material difference between the two randomised treatment strategies in terms of the study primary endpoints . These conclusions are both ‘correct’ within the particular statistical framework chosen by the trial investigators.

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Great appearance and smile, conveying his enjoyment of the magic. The Ascent is a Motley Fool service that rates and reviews essential products for your everyday money matters. We’re firm believers in the Golden Rule, which is why editorial best security practices for your deribit account opinions are ours alone and have not been previously reviewed, approved, or endorsed by included advertisers. Editorial content from The Ascent is separate from The Motley Fool editorial content and is created by a different analyst team.

• Tse is a serial high tech startup founder with a previous company sale to Apple, Inc. and project work for Google.
• However, the relationship between OneCoin andblockchain technologywas only in the description and not in practice.
• In November 2019, Ignatov pleaded guilty to charges of money laundering and fraud.
• When you click through from our site to a retailer and buy a product or service, we may earn affiliate commissions.
• And this year, the headlines have been full of stories of huge rewards and crypto millionaires.
• The man accused of laundering over $100 million for OneCoin founder Ruja Ignatova is set to be extradited to face fraud charges in the United States after a British judge dismissed his attempt to delay the process.

This is reflected in regulatory agency guidelines, CONSORT statements on the reporting of trials and review articles . Focussing on non-regulatory trials with a public health objective, our article challenges this dogma. The Federal Bureau of Investigation has continued its educational journey on digital asset-related scam cases. In its latest official podcast episode, the bureau zeroed in on Ruja Ignatova, the co-founder of the OneCoin “blockchain” platform that allegedly defrauded investors of over $4 billion.

What Makes Harmony Different From Others?

On 23 April 2017, Indian police arrested 18 people in Navi Mumbai for organizing a OneCoin recruitment event. The police attended the event undercover to judge the accusations before they decided to act. Further investigation was begun with the intent of revealing the higher levels of the pyramid. In May, the investigation recovered Rs 24.57 crores ($3.32 million USD) in nine bank accounts. A further Rs 75 crores ($10.12 million USD) were transferred out before authorities were able to seize it. Early in the month of May two more people were arrested and a further Rs 24 crores ($3.24 million USD) were seized from bank accounts.

Not everyone can perform it with the same kind of charm that Moritz has, but it’s still worth learning. I really enjoyed learning this (also his Mo-Fly routine, available elsewhere) and feel that it’s a great value for the money. For me as complete newbie in coin-magic, this was my first coin-routine i ever buyed. I love a routine you can do with pretty much any coin, anywhere, anytime! I love the routine… gives me a new perspective and handling of the coins.

Iran pushes to rein digital assets with the launch of ‘crypto rial’

Sadly, crypto’s short history is already littered with stories of fraudsters, and OneCoin was one of the biggest. OneCoin’s leaders stole more than $4 billion from investors around the world over several years. Iran is eager to make a name for itself in the global digital asset industry as it prepares for the phased adoption of its CBDC while Southeast Asia braces for more crackdowns as the market stumbles. Ethereum,FTXandTether—who have co-opted the digital asset revolution and turned the industry into a minefield for naïve players in the market. Harmony is an open blockchain network and decentralized ecosystem that seeks to scale the use case for decentralization as a fully commercial, faster, secure and reliable payment processing option.

We argue that the superiority/non-inferiority framework is not just unnecessary but can have a detrimental effect, being a barrier to clear scientific thought and communication. In particular, it places undue emphasis on tests for significance or non-inferiority at the expense of estimation. We emphasise that these concerns apply to phase 3 non-regulatory trials in general, not just to those where the classification of the trial as superiority or non-inferiority is ambiguous. It is widely accepted that important differences exist between superiority and non-inferiority trials in terms of their design, analysis and interpretation.

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You should always try to find out why the coin isn’t easy to buy, and don’t trust a coin that only works on its own exchange and nowhere else. The founders also operated it as a multi-level marketing scheme where users get “perks” for referring others. Ignatova bragged in 2016 that the platform had over two million active users and more than 12 million entry points even without an accurate way to track any metrics except through the company’s words. Founded in 2014, Bulgaria-based firm OneCoin is an alleged crypto exit scam that reportedly raised $4.4 billion in a Ponzi scheme and laundered $400 million over its years of operation. Co-founder Konstantin Ignatov pleaded guilty to those charges, while his sister and co-founder Ruja Ignatova, also known as “cryptoqueen,” is currently a fugitive. The company has since been hit by a massive class-action lawsuit, with legal proceedings currently ongoing.

If you are a part of an investment forum that uses similar tactics, be careful. It is easy to get emotionally drawn in, especially when your money is on the line. But investigative journalists rarely a guide to trading and investing in cryptoassets criticize a project just for the fun of it or because they don’t like someone. Listen to the critics and evaluate their comments — then you can decide for yourself if their argument has merit.

A recent paper argues that a clear distinction should be made between statistical and clinical superiority, along with consistent presentation of two-sided CIs . ZDNET’s recommendations are based on many hours of testing, research, and comparison shopping. We gather data from the best available sources, including vendor and retailer listings as well as other relevant and independent reviews sites. And we pore over customer reviews to find out what matters to real people who already own and use the products and services we’re assessing. Another simple method is to search the internet for “” and “scam.” You may find unfair accusations from disgruntled investors who lost money when the price fell, but the comments are still worth reading. Also use sites like Token Sniffer and Coinopsy, as they flag potential scam or dead coins.

The FBI is offering a reward of up to $100,000 for information leading to the arrest of Bulgarian-born Ignatova, who disappeared in 2017. Please also note that data relating to the above-mentioned cryptocurrency presented here are based on third party sources. They are presented to you on an “as is” basis and for informational purposes only, without representation or warranty of any kind. Links provided to third-party sites are also not under Binance’s control.

Superiority and non-inferiority: two sides of the same coin?

Needs to review the security of your connection before proceeding. A Singapore man was fined $72,000 for operating a multi-level marketing scheme linked to the Ponzi scheme OneCoin. The percent change in trading volume for this asset compared to 7 days ago. The percent change in trading volume for this asset compared to 24 hours ago. The percent change in trading volume for this asset compared to 1 hour ago. The price of Bitcoin varies, but as of June 2022, was trading at $27,333.

• Early in the month of May two more people were arrested and a further Rs 24 crores ($3.24 million USD) were seized from bank accounts.
• Ruja Ignatova started OneCoin in 2014, claiming it worked just like any other cryptocurrency.
• Jake Frankenfield is an experienced writer on a wide range of business news topics and his work has been featured on Investopedia and The New York Times among others.
• OneCoin’s leaders stole more than $4 billion from investors around the world over several years.
• Fintech, a portmanteau of “financial technology”, is used describe new tech that seeks to improve and automate the delivery and use of financial services.

The FBI says it is possible she was tipped off about her being put under investigation. Deep sharding on the Harmony blockchain is quite different from that on any other blockchain developed to date. Deep sharding allows for independent processes to be completed on the Harmony blockchain. This ensures high speeds inthe Harmony network, which seeks to compete with mainstream centralized and traditional finance payment systems. Market cap is calculated by multiplying the asset’s circulating supply with its current price.

• “Crypto Queen” promises to shed exclusive new light on one of the biggest digital scams of the last decade.
• The FBI says it is possible she was tipped off about her being put under investigation.
• However, there was no OneCoin blockchain model or payment system.